RET, ret proto-oncogene, 5979

N. diseases: 607; N. variants: 162
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease HPO
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Medullary thyroid carcinoma in a child with a new RET mutation and a RET polymorphism. 15844786 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma. 18226854 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements. 18756447 2009
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onset. 14557473 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Germline homozygous mutations at codon 804 in the RET protooncogene in medullary thyroid carcinoma/multiple endocrine neoplasia type 2A patients. 15741265 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Three novel mutations in the RET proto-oncogene. 11692159 2001
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 AlteredExpression disease LHGDN RET expression in papillary thyroid cancer from patients irradiated in childhood for benign conditions. 12161537 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg. 16419493 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 AlteredExpression disease LHGDN Emergence of medullary thyroid carcinoma in a family with the Cys630Arg RET germline mutation. 15523405 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Papillary thyroid carcinoma in patients with RET proto-oncogene germline mutation. 12193298 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Significance of the RET proto-oncogene polymorphisms in Turkish sporadic medullary thyroid carcinoma patients. 17185892 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Molecular analysis of the RET and NTRK1 gene rearrangements in papillary thyroid carcinoma in the Polish population. 16483615 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements. 17464312 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement. 11927965 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN A new germline point mutation in Ret exon 8 (cys515ser) in a family with medullary thyroid carcinoma. 18631007 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN The RET IVS1-126G>T variant is strongly associated with the development of sporadic medullary thyroid cancer. 15142370 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN In conclusion, we found RET amplification, which is a rare oncogenic aberration, in thyroid cancer. 17270245 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer. 15273715 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN Here, we show that nuclear localization of beta-catenin is frequent in both thyroid tumors and their metastases from MEN 2 patients, suggesting a novel mechanism of RET-mediated function through the beta-catenin signaling pathway. 18316596 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804. 11932300 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN [Analysis of mutations in the RET proto-oncogene in patients with medullary thyroid tumor]. 12884527 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN RET signals through focal adhesion kinase in medullary thyroid cancer cells. 15657578 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN RET/PTC and CK19 expression in papillary thyroid carcinoma and its clinicopathologic correlation. 15716612 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN [RET mutations and preventive treatment of medullary thyroid cancer]. 15988377 2005